RESEARCH OPPORTUNITIES FOR UNDERGRADUATE AND MEDICAL STUDENTS
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| The Department of Urology has a variety of research opportunities
for undergraduates planning a career in basic research or medicine as well as
for medical students interested in exploring Urology as a possible specialty.
The basic research projects are conducted in the Jim & Eilleen Dicke Research
laboratory located on the ground floor of the Wood Research Tower. Basic
research projects are directed by Dr. Sanjay Gupta, PhD, a principal investigator. For
interested students we are able to provide clinical exposure to Urology. The
department also has an active clinical research program investigating outcomes
and treatment efficacies for a variety of urologic problems. Appropriate
clinical research opportunities for medical students are frequently available. |
Dr. Sanjay Gupta, PhD
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Prostate Cancer & its Prevention: The research focuses on identification
of novel targets and surrogate biomarkers for early detection and prognosis of
prostate cancer. The other component of our research is cancer chemoprevention,
a means of cancer control in which the occurrence of clinical cancer can be
prevented, slowed or reversed by the administration of one or more synthetic or
naturally occurring biologic compounds. We are using all relevant models of
prostate cancer ranging from cell culture, transgenic mouse models and human
prostate tissue to conduct our studies. Our current interest is on diet-based
bio-active agents which include apigenin, a common plant flavonoid,
green tea polyphenols, tocotrienol-rich fraction from palm oil, chamomile, and
D-limonene, a monoterpene found in citrus fruits and
citrus peel oil as putative agents for prostate cancer chemoprevention. |
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Shukla S, MacLennan GT, Marengo SR, Seftel AD, Resnick MI, and Gupta S: Genetic
abnormalities in prostate cancer. Current Genomics 5: 67-83, 2004. |
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Shukla S and Gupta S: Dietary agents in chemoprevention of prostate cancer. Nutrition and Cancer 53:18-32, 2005.
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Prostatitis: Chronic nonbacterial prostatitis is responsible for more
visits to physicians than either prostate cancer or BPH. Recent studies have
suggested that chronic prostatic inflammation may foster the development of
prostate cancer. Despite its prevalence, almost nothing is known about the
disease's etiology or the nature of the inflammatory response. To address this,
we are using animal models of prostatitis, human prostate specimens and flow cytometry
to determine the functional lymphocyte subsets participating in prostatic inflammation. |
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MacLennan GT, Eisenberg R, Fleshman RL, Taylor JM, Fu P, Resnick MI, Gupta S:
The influence of chronic inflammation in prostatic carcinogenesis: a 5-year followup study. J Urol. 176:1012-6, 2006. |
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Vykhovanets EV, Resnick MI, MacLennan GT, Gupta S:
Experimental rodent models of prostatitis: limitations and potential. Prostate Cancer Prostatic Dis. 10:15-29, 2007. |
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